• Aprotinin Although CP has been an important research

  2025-04-22

  

  Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular Aprotinin by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an involvement of au

• br Results and discussion br

  2025-04-21

  

  Results and discussion Conclusion A series of aminobenzothiazole derivatives were investigated as possible Aurora B kinase inhibitors. Bioisosteric replacement of the heterocyclic core of the lead compound was performed regarding the docking analysis. Replacement of the oxygen HotStart™ 2X Gre

• Aurora A the polar kinase is located at the

  2025-04-21

  

  Aurora A the ’polar kinase’ is located at the centrosome and is required for its maturation, division, for the mitotic spindle assembly and entry into mitosis., Mutation or transcriptional silencing of Aurora A impairs centrosome maturation and separation, leads to mono/multipolar spindles, to dela

• br Conflict of interest statement

  2025-04-17

  

  Conflict of interest statement Acknowledgments Introduction Cellular responses to genotoxic stress in eukaryotic cells are coordinated by members of the phosphoinositide kinase related protein kinase (PIKK) family. Two members of this family, Ataxia–Telangiectasia mutated (ATM) and ATM and

• br Mechanisms of GPCR internalization Like for other

  2025-04-16

  

  Mechanisms of GPCR internalization Like for other types of receptors, prolonged agonist stimulation often leads to GPCR internalization, which can occur via different pathways ∗[2], [20], [21], [22], [23]. Of these pathways, clathrin-mediated Nitrocefin (CME) is the best characterized and arguabl

• Because ASK signaling in microglia and astrocytes

  2025-04-15

  

  Because ASK1 signaling in microglia and astrocytes is important during EAE, we hypothesized that a combination therapy that targets T cells along with microglia and astrocytes would further ameliorate the severity of EAE. We tested this hypothesis by applying valproic VX-765 (VPA)—a short-chain fat

• br Material and methods br Results br

  2025-04-14

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential EZ Cap™ Cy5 EGFP mRNA (5-moUTP) for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacteria

• br Materials and methods br Results br Discussion

  2025-04-12

  

  Materials and methods Results Discussion The current treatment modalities for colorectal cancer are hampered by various issues such as high acquired resistance, long-term complication with potential of cancer recurrence, severe side-effects and poor therapeutic index [50], [51], [52]. Compl

• The renin angiotensin system RAS is a hormonal system which

  2025-04-02

  

  The renin-angiotensin system (RAS) is a hormonal system which plays a role in the regulation of blood pressure and body fluid Sulfo-NHS-Biotin [14]. The main bioactive peptide of RAS is angiotensin II (Ang II) whose biological functions are interposed through angiotensin type 1 receptor (AT1R) and a

• First the complete canonical brain original RAS

  2025-04-01

  

  First, the complete canonical brain original RAS (Angiotensinogen, Renin, Angiotensin I, Angiotensin Converting Enzyme (ACE), Angiotensin II) has not been conclusively identified in any specific cell type within the brain [1]. Validated evidence for the presence of brain Angiotensinogen and ACE was

• br Duality of interest br Contribution statement

  2025-03-31

  

  Duality of interest Contribution statement Acknowledgments Introduction Rapid, cell surface-initiated steroid actions have been reported for all major groups of steroid hormones and our understanding of membrane-mediated steroid actions has progressed rapidly over the last two decades. M

• Cell Counting Kit-8 (CCK-8) Several mechanisms of Cd induced

  2025-03-31

  

  Several mechanisms of Cd-induced carcinogenicity have been reported and are comprehensively summarized by Hartwig [32]. As early as 1980, basic science studies supported a role for endocrine disruption of AR by Cd. Donovan et al. [33], using extracts of mouse prostate cytosol, showed Cd to be the mo

• br Role of AR in models of neointima

  2025-03-29

  

  Role of AR in models of neointima formation Investigations into the pathogenesis of lesion formation have often used acute models of mechanical damage to assess the mechanisms regulating the fibro-proliferative response to arterial injury. Models of acute injury used for this purpose include: lig

• Prestained Protein Marker (Triple color, EDTA free, 10-250 k

  2025-03-28

  

  Similarly, results obtained in our lab using experimental diabetic encephalopathy induced by streptozotocin (STZ) in C57BL-6 mice showed that the hippocampus of the diabetic animals exhibited reactive gliosis, neuronal loss, NF-kB signaling activation as well as high levels of IL-1β and vascular end

• VX-765 Cell surface metalloproteases coordinate signaling du

  2025-03-27

  

  Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. A disintegrin and metalloprotease 17 (ADAM17) is a well-characterized member among ADAM family, which mediates the cleavage of various cell surface proteins (Black, 2002, Black et al., 1997, Dello

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