• In liver the essential organ of

  2024-03-15

  

  In liver, the essential organ of lipoprotein synthesis, ACL plays a fundamental role in lipogenesis and steroidogenesis by supplying cytosolic SGC-CBP30 to both pathways. By using a tricarboxylic acid cycle intermediate (citrate) to produce acetyl CoA, ACL can be seen as an important bridge between

• Knowledge about adipose tissue has evolved considerably

  2024-03-15

  

  Knowledge about adipose tissue has evolved considerably over the last two decades. Always been described as an inert tissue having the function of stocking lipids, adipose tissue is now recognized as a real organ with both metabolic and endocrine functions secreting various factors into the blood to

• Apelin is a bioactive peptide and endogenous ligand for

  2024-03-15

  

  Apelin is a bioactive peptide and endogenous ligand for the APJ receptor (APLNR), a member of the G protein coupled receptor family that shares a similar sequence as the angiotensin type-1 receptor (AT1) [5]. Early studies demonstrated that the apelin/APLNR receptor axis plays a significant role in

• br Materials and method br Results br Discussion Although se

  2024-03-15

  

  Materials and method Results Discussion Although several studies have showed the crude extracts of K. senegalensis possessed the anti-inflammatory and hypertensive activities (Olayinka et al., 1992). However, the anti-inflammatory effect and underlying molecular mechanisms of its bioactive

• Finally we argue that the estimated penetrance

  2024-03-14

  

  Finally, we argue that the estimated penetrance of 0.45% (95% CI 0.02%, 9.35%) calculated by leveraging the gnomAD (Lek et al., 2016) population data indicate that T201S is at most a low-risk gene variant for CJD. If we arbitrarily consider a central estimate of 10% or higher as the clinically signi

• RVX-208 synthesis Sorafenib was the first small RTK inhibito

  2024-03-14

  

  Sorafenib was the first small RTK inhibitor drug to be developed and was initially approved against renal cell carcinoma, then against hepatocellular carcinoma (HCC) and more recently for differentiated thyroid treatment [111]. Sunitinib soon followed, being approved for gastrointestinal stromal tum

• br Antiangiogenic therapy in non small

  2024-03-14

  

  Antiangiogenic therapy in non-small cell lung cancer (NSCLC) Antiangiogenic targeted therapy is an area of active research in which numerous agents have been studied and have been shown to be effective for many tumor types including NSCLC. Angiogenesis is frequently upregulated in malignant solid

• Lamivudine br Theoretical mechanism of ABCA activity in LE

  2024-03-14

  

  Theoretical mechanism of ABCA2 activity in LE/LY in modulation of cholesterol trafficking It is important to confirm that ABCA2 is a lipid transporter and identify the substrates that are mechanistic in its cholesterol sequestering activity. We hypothesize that ABCA2 modulates cholesterol sequest

• An important observation in our study is the lack

  2024-03-14

  

  An important observation in our study is the lack of effect of paroxetine pretreatment alone on β2AR membrane expression, which suggests that paroxetine, and pharmacologic inhibition of GRK2 in general, does not directly induce changes in receptor dynamics. Rather, the decreased ligand-induced β-arr

• br Conflict of interest br Acknowledgement This study

  2024-03-14

  

  Conflict of interest Acknowledgement This study was supported by a grant from University Grants Commission - Basic Scientific Research (UGC-BSR), New Delhi, India (UGC-BSR No:F-7-115/2007). Introduction The G protein-coupled receptors activated by extracellular adenosine (Ado), called Aden

• br Methods br Results br Discussion First

  2024-03-14

  

  Methods Results Discussion First, the Xylometazoline HCl isolated from non-PD TA tissue and PD plaque tissue were characterized. The results showed that both cell groups were positive for vimentin and negative for desmin suggesting that these cells were fibroblasts. It was also observed th

• br Materials and methods br Results br Discussions Diabetes

  2024-03-14

  

  Materials and methods Results Discussions Diabetes is mainly divided into Type 1 diabetes and Type 2 diabetes [16]. Type 2 diabetes, featured by insulin resistance, results from environmental factors and poor eating habits [2]. Type 2 diabetes accounts for more than 95% of the diabetic pati

• PL for actin in vitro showed that

  2024-03-14

  

  PL for L-745,870 trihydrochloride receptor in vitro showed that its profiles, including particular peak and intensity, could determine the length and thickness of an actin filament. Furthermore, we investigated if the PL intensity peak at approximately 340 nm can also be originated from another cyt

• Recent studies have indicated that V ATPase activity negativ

  2024-03-13

  

  Recent studies have indicated that V-ATPase activity negatively regulates vacuolar fusion in vivo[17]. Since we have demonstrated that the pah1Δ Rimonabant have a more acidic vacuolar pH than the WT cells, and the genes involved in the pump activity are upregulated compared to WT, the pah1Δ cells' a

• In the pituitary of R quelen mRNA

  2024-03-13

  

  In the pituitary of R. quelen mRNA levels of cyp19a1b were found to be higher in males than females, suggesting a sex-specific function, and perhaps a local action to regulate gonadotropins or other pituitary hormone secretion (Olivereau and Callard, 1985; Zhang et al., 2014). Interestingly, the hig

16292 records 185/1087 page Previous Next First page 上5页 181182183184185 下5页 Last page