• Advances in the total chemical synthesis of ubiquitin have

  2019-09-20

  

  Advances in the total chemical synthesis of ubiquitin have enabled the efficient synthesis of new and improved ubiquitin-based reagents. Using an optimized linear synthesis, ubiquitin can now be easily obtained in high yield and purity [35]. Using this synthetic methodology, ubiquitin can be functio

• 43 7 mass It was hypothesized that if modafinil acts

  2019-09-20

  

  It was hypothesized that if modafinil acts primarily via a noradrenergic mechanism, Dbh −/− mice should be non-responsive since they completely lack NE. In contrast, if modafinil acts mainly through DA systems, these mice should be hypersensitive. Modafinil was tested in Dbh −/− mice using both loco

• Both meiotic COs and NCOs require DNA

  2019-09-20

  

  Both meiotic COs and NCOs require DNA synthesis, current data from sequencing also suggest that COs require more DNA synthesis than NCO 63., 64., 65.. However, analysis of the role of DNA synthesis in NCOs remains relatively uncharacterized. Emerging evidence points to a role for either Polδ or Polε

• In this context we initiated a program to

  2019-09-20

  

  In this context, we initiated a program to develop new antiviral chemotypes towards a host factor implicated in WIN 18446 replication: the host (human) dihydrofolate reductase (DHFR) [21]. We recently identified this enzyme as the molecular target of 1-aryl-4,6-diamino-1,2-dihydrotriazines, structu

• molarity of a solution Aspergillus nigerA niger is another f

  2019-09-20

  

  Aspergillus nigerA. niger is another filamentous fungus, in which alternative dehydrogenases have been described. Filamentous fungi are a very important group of microorganisms that are used in industry (O’Donnell et al. 2011). Biotechnological production processes using these organisms are often hi

• In humans CYP A major isoforms of CYP As

  2019-09-20

  

  In humans, CYP3A4/5, major isoforms of CYP3As in the liver, have variants that reduce the enzyme activities [33], [34]. In addition, Werk et al. recently reported the first case of a complete failure of CYP3A enzyme activity due to homozygous loss-of-function mutation of CYP3A4 combined with nonfunc

• Besides being an energy storing tissue adipose tissue

  2019-09-20

  

  Besides being an energy storing tissue, adipose tissue acts as an active endocrine organ that secretes a number of biologically active adipokines involved in multiple physiological processes such as inflammation and lipid and glucose metabolism, with direct and indirect effects on reproduction [15,1

• CK enzymes belong to a conserved

  2019-09-20

  

  CK1 enzymes belong to a conserved family of serine/threonine protein kinases that plays an important and diverse role in vesicular trafficking, DNA repair, alizarin progression and cytokinesis in organisms from yeast to humans [15]. In multicellular organisms CK1 enzymes also regulate developmental

• The highest concentrations from several tens

  2019-09-20

  

  The highest concentrations (from several tens to often hundreds or thousands ng/L) are reported in animal farm flush water, and associated runoffs and lagoons in China and in the U.S. Lower concentrations are reported in WWTP influents and effluents. In WWTP influent waters DRO, LNG, NET and PRG hav

• The Nile tilapia Oreochromis niloticus is an important farme

  2019-09-19

  

  The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al

• Cytochromes P CYP are a superfamily of hemoproteins containi

  2019-09-19

  

  Cytochromes P450 (CYP 450) are a superfamily of hemoproteins containing a heme cofactor, which are widely distributed in animals, plants and microbes (Hannemann et al., 2007). CYP450 exhibits a variety of biological functions including biotransformation of drugs, detoxification of endogenous and xen

• Grapiprant is a selective antagonist for prostaglandin E PGE

  2019-09-19

  

  Grapiprant () is a selective antagonist for prostaglandin E (PGE) receptor subtype 4 (EP4) identified as a clinical candidate for the treatment of inflammatory pain associated with osteoarthritis (OA). It is currently under development for use in humans and dogs. The projected dosing regimen of grap

• To our knowledge this is the first report

  2019-09-19

  

  To our knowledge, this is the first report of an oncocytoma expressing alpha-enolase or causing autoimmune retinopathy and optic neuropathy. Although generally considered benign, oncocytomas have rarely been associated with paraneoplastic syndromes, including tumor-induced hypertension, erythrocytos

• Given its high frequency it is

  2019-09-19

  

  Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant VPS34-IN1 kinase to EGFR inhibition. To date, several different strategies have been evaluated in both preclinical and clinical models, but only few have been

• br The classical ubiquitination pathway

  2019-09-19

  

  The classical ubiquitination pathway Ubiquitination is an enzymatic process that involves the addition of an ubiquitin protein to a substrate that usually becomes inactivated followed by degradation in the proteasome; however, several other functions have also been described. For the discovery of

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