• br Discussion Cytomegalovirus CMV is a herpes virus that

  2020-12-24

  

  Discussion Cytomegalovirus (CMV) is a herpes virus that causes primary infection in normal hosts and re-activation infection in compromised hosts with impaired CMI, e.g., organ transplants. Following primary infection, which may be severe, CMV becomes latent in lymphocytes. Reactivation may occur

• br Materials and methods br Results br Discussion

  2020-12-24

  

  Materials and methods Results Discussion One novel finding in our study is that CK2 inhibition preserved axon function and structure in WM against ischemia. Consistent with these findings, oligodendrocytes, astrocytes, myelin, and NGB 2904 were found to express CK2α. The robust expression

• br Acknowledgements This work was supported by a grant from

  2020-12-24

  

  Acknowledgements This work was supported by a grant from the Deutsche Forschungsgemeinschaft to Uwe Knippschild and Martin Wabitsch (SFB 1149/B4). P. Fischer-Posovszky is funded by a Margarete von Wrangell scholarship financed by the Ministerium für Wissenschaft, Forschung und Kunst Baden-Württem

• A limitation of this study

  2020-12-24

  

  A limitation of this study is the between-study heterogeneity of the datasets analyzed. To address this heterogeneity, we used a random-effects model in our analysis. Also, only 2 of the databases provided information on sex, and as a result, the sex-specific analyses were performed with a smaller c

• Co operation or synergy between PKA and

  2020-12-24

  

  Co-operation or synergy between PKA and Epac has been recently reported in PCCL3 thyroid cell line in which cAMP is pro-mitogenic, in carboxypeptidase a to VSMC [19]. Our study demonstrates for the first time that PKA and Epac also synergise to inhibit cell proliferation in a cell type where cAMP in

• Prostaglandins PGs in particular PGE

  2020-12-24

  

  Prostaglandins (PGs), in particular PGE2 and PGF2α, play pivotal roles in human parturition by stimulating cervical ripening, myometrial contraction and fetal membrane rupture (Challis et al., 1997). In human pregnancy, the amnion is the principle source of PGE2 (Duchesne et al., 1978). In the amnio

• Enzyme mimics belong to a type of rising catalysts

  2020-12-24

  

  Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a

• In contrast a single instillation of BLM results in

  2020-12-24

  

  In contrast, a single instillation of BLM results in a progression of inflammatory events that culminates in marked remodeling of the lung interstitium. This process takes 2–3 weeks, with the fibrotic lesions becoming most pronounced within the first month [9]. Consequently, the BLM model offers the

• br Abbreviations br Introduction br Collagen induced

  2020-12-24

  

  Abbreviations Introduction Collagen-induced DDR activation A key feature of DDRs is their ability to bind both fibrillar and non-fibrillar collagens (Shrivastava et al., 1997, Vogel et al., 1997). DDR1 and DDR2 recognize the GVMGVO (O, hydroxyproline) motif within fibrillar collagens I–III

• br Conclusion The present study is the

  2020-12-24

  

  Conclusion The present study is the first to provide in vivo evidence that the σ1R deficiency can cause age-related increases in aggregation and phosphorylation of αSyn in dopaminergic neurons of SNpc. The σ1R has been reported to be decreased in the Penciclovir Sodium synthesis region of the ni

• At baseline mutant allele frequency of EGFR in tissue

  2020-12-24

  

  At baseline, mutant allele frequency of EGFR in tissue and plasma samples did not correlated with anti-tumor response (Supplementary Fig. 1). Among 35 patients who were positive for cell-free DNA (cfDNA) at baseline, changes of cfDNA during treatment were analyzed. Negative conversion (NC) of cfDNA

• First KEGG and GO annotation were conducted for these

  2020-12-24

  

  First, KEGG and GO annotation were conducted for these 1251 genes. Then, combining the pathway enrichment analysis, we explored how these genes could function in breast cancer. We discovered that neuroactive ligand-receptor interaction was the most enriched pathway, which comprised numerous G protei

• Two primary members of the TRIM family

  2020-12-24

  

  Two primary members of the TRIM family – TRIM5α and TRIM25 – function as antiviral effector and immune regulator, respectively. TRIM5α is one of the best characterized members of the TRIM family (both structurally and functionally) and reported to be an important ubiquitin-mediated regulator of a ma

• br A brief introduction to

  2020-12-23

  

  A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating Dehydroepiandrosterone mg (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs which can be

• Homatropine Methylbromide br Development of the double stran

  2020-12-23

  

  Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using Homatropine Methylbromide in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by

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