• br Conclusion br Acknowledgments This research was funded by

  2022-05-04

  

  Conclusion Acknowledgments This research was funded by Tianjin Health Institution Key Projects, grant number 15KG148” and “Tianjin Medical University General Hospital Youth Incubation Fund, grant number ZYYFY2017029”. I would like to express my heartfelt gratitude to Professor Hongtao Zhang fo

• The characterization of Da CTSL shows that

  2022-05-04

  

  The characterization of Da-CTSL1 shows that it preferentially cleaves Z-FR-AFC (Fig. 8), which has a Zinc protoporphyrin IX receptor phenylalanine at P2 and Da-proCTSL1 is autocatalyzed at pH 8.0 releasing an activated Da-CTSL1 that exhibits optimal activity at pH 8 indicating that the enzyme when s

• br Structural studies of GCAP Recoverin was the

  2022-05-04

  

  Structural studies of GCAP Recoverin was the first member of this subfamily of Ca2+-binding 2-Amino-ATP to be investigated by structural methods [27], [54], [55], [56], [57], [58]. These proteins have four EF-hands arranged in pairs that give rise to amino- and carboxyl-terminal domains. The cry

• PTMs have been shown to influence transporter

  2022-05-04

  

  PTMs have been shown to influence transporter kinetics, both directly and indirectly (Xu & You, 2017). They do not just regulate the innate structure-function relationship driven by a transporter's global architecture, but rather are also able to regulate this relationship down to the resolution of

• Polyunsaturated fatty acids PUFAs represent a class of lipid

  2022-05-04

  

  Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic HO-3867 (DHA), eicosapentaenoic acid (EPA) and n-6 such as arachidonic acid (AA

• br Acknowledgements This work was supported by

  2022-05-04

  

  Acknowledgements This work was supported by the National Institutes of Health [grant number GM024417]. Introduction In mammals, glucose is the major energy substrate supporting conceptus development after [Ala92]-p16 (84-103) formation [1,2]. While the equine morula uses similar amounts of p

• The caseins are a family of milk phosphoproteins

  2022-05-04

  

  The caseins are a family of milk phosphoproteins whose biological function is to provide supersaturating concentrations of calcium, phosphates, and essential adrenergic antagonist to the neonate (Vonderhaar and Ziska, 1989). α- and β-caseins, the most abundant of the milk caseins, are described as c

• Murine models of sickle disease have been valuable tools

  2022-05-04

  

  Murine models of sickle disease have been valuable tools in the study of human SCD pathogenesis [15], [16], and will continue to be central to development of novel approaches to disease treatment. The SAD mouse model of sickle disease is particularly remarkable for its erythrocyte dehydration phenot

• NVP-AEE788 Sickle erythrocytes are known to

  2022-05-04

  

  Sickle erythrocytes are known to have an increased adhesion to endothelial NVP-AEE788 (Hebbel et al., 1980, Hebbel et al., 1981a, Hebbel et al., 1981b, Wautier et al., 1985, Mohandas and Evans, 1987). Understanding the events associated with vaso-occlusion requires a detailed knowledge of the intera

• br GJs in the brain br Alterations

  2022-05-04

  

  GJs in the brain Alterations of GJs in epilepsy The role of GJ blockers and openers in epilepsy As previously known, GJ-mediated electrical coupling plays a role in the generation of highly synchronous electrical activity. The hypersynchronous neuronal activity is a significant feature of c

• The focused set of additional pyrazole analogs

  2022-05-04

  

  The focused set of additional pyrazole analogs allowed the identification of three additional moderately potent γ-secretase modulators, , and which were subsequently screened in a kinetic solubility assay. Unfortunately, neither the architectural changes in analog nor the integration of trifluoro su

• Autophagy plays a multifaceted role in

  2022-04-29

  

  Autophagy plays a multifaceted role in regulating both the quality and quantity of protein (e.g., protein half-life and activity) and organelles (e.g., mitochondrial number and function), thus determining cell fate [15]. The induction of autophagy has been generally considered a programmed cell surv

• To evaluate the role of increased FPPS expression in

  2022-04-29

  

  To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on Z VDVAD FMK progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-treated cells (A and B

• Additionally to their peripheral effects evidence indicate a

  2022-04-29

  

  Additionally to their peripheral effects, evidence indicate a role for ETs in the central nervous system (Mosqueda-Garcı́a et al., 1993). Indeed, using Northern blot analysis and in situ hybridization it has been shown the presence of immunoreactive ET of non-vascular origin and of neuronal location

• Dithiodipyridine also known as aldrithiol is a known zinc ej

  2022-04-29

  

  2,2′-Dithiodipyridine , also known as aldrithiol, is a known zinc ejector, targeting for instance the zinc finger in nucleocapsid protein of human immunodeficiency XL-888 type 1. inhibited G9a activity with IC = 0.65 µM and GLP with IC = 2.6 µM. We also tested disulfide cysteamine dihydrochloride s

15863 records 445/1058 page Previous Next First page 上5页 441442443444445 下5页 Last page